Research progress of biosensors for detection of SARS-CoV-2 variants based on ACE2Article Published on 2023-01-012022-11-15 Journal: Talanta [Category] SARS, 변종, 치료기술, [키워드] Accuracy ACE2 acute respiratory syndrome addition antibody biosensor biosensors caused Cell cells complex coronavirus coronavirus disease COVID-19 detect detection Diagnosis drug evaluated gold standard Health increase Interaction modulate Mutation Novel coronavirus pandemic Prevent receptor RT-PCR SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2. the spike protein time-consuming variants Variation virus virus mutations [DOI] 10.1016/j.talanta.2022.123813 PMC 바로가기
Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants [DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article
ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific mannerArticle Published on 2022-11-052022-11-16 Journal: Communications Biology [Category] SARS, 변종, [키워드] accumulated ACE2 ACE2 receptor binding binding site caused cellular changes in conserved Delta glycan glycosylation glycosylation deletion glycosylation site Guidance Interaction investigated lineages modulate mutated N-glycosylation omicron parental profile provide SARS-CoV-2 SARS-CoV-2 spike protein soluble ACE2 spike spike mutation the SARS-CoV-2 therapeutic use variant variants of concern virus VOCs [DOI] 10.1038/s42003-022-04170-6 PMC 바로가기
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cellsArticle Published on 2022-11-012022-11-15 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 진단, [키워드] 16HBE 16HBE cell 16HBE cells 6-O-angeloylplenolin ACE2 ACE2 expression addition administration Cell Centipeda Centipeda minima chemokine Chinese Compound conducted COVID-19 CX3CL1 CXCL13 dataset demonstrated downregulated entry of SARS-CoV-2 enzyme evaluated expression gene encoding HLF IL-6 inhibited inhibitor Interaction lung epithelial cell Lung epithelial cells lung tissue lung tissues mice modulate parental pathogen phosphorylated positively correlated promoter PROTECT Protein pseudovirus receptor reduced regulate Regulation S protein SARS-CoV-2 SARS-COV-2 infection screened STAT3 STAT3. stimulated suppressed target cells tested TFS Transcription transcription factor transfected with [DOI] 10.1038/s41401-022-00906-6 PMC 바로가기
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airwaysArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 airway airway epithelium airways association C15orf48 cell population changes in characterized club co-expressed cohorts CTSL diagnostic workup disease severity elevated epithelial cells expressed expressing expression expression data Gene Expression gene expression pattern Goblet cell increase in indicated individual Infection lung cancer lung cancer risk modulate modulated nasal Population SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection scRNA-seq secretory cell severe disease significantly similarity smoker smoking smoking status subpopulation TMPRSS2 viral entry Viral load [DOI] 10.1038/s41598-022-17832-6 PMC 바로가기
Vitamin D enhances type I IFN signaling in COVID-19 patientsArticle Published on 2022-10-222022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% confidence interval adjusted hazard ratio Admission all-cause mortality antimicrobial peptide Antiviral Antiviral effect antiviral response collected COVID-19 infection COVID-19 patient ENhance Host host response IFN in vitro intensive care interferon investigated ISGs JAK-STAT signaling pathway lower risk modulate on type outcome patient survival patients PBMC protein level Regulatory saliva specimen SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient Signaling significantly higher treated treated patient treated patients Treatment Type I IFN untreated patient Vitamin D Whole blood [DOI] 10.1038/s41598-022-22307-9 PMC 바로가기
Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulinArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] abrogation Activation acute respiratory distress addition Alter ARDS cell-free DNA circulation Clinical treatment Corticosteroids Course COVID-19 COVID-19 patient Critically ill Dexamethasone dose-dependent elevated Ex vivo Factor functions healthy controls healthy donor healthy donors IL-8 inflammatory pathway Intravenous immunoglobulin Intravenous immunoglobulin (IVIG) lack Level Lung injury lung parenchyma modulate NET NETosis NETs neutrophil Neutrophil elastase Neutrophil extracellular trap neutrophil function Neutrophils not affect oxidative oxidative burst Patient Peripheral blood phagocytosis PMA pro-inflammatory function Proteins reactive oxygen specy reduced reduction severity syndrome targeting therapeutic therapeutic agent Tocilizumab tocilizumab. treated Treatment were assessed while with COVID-19 [DOI] 10.3389/fimmu.2022.993720 PMC 바로가기
Glycyrrhizin through liquorice intake modulates ACE2 and HMGB1 levels-A pilot study in healthy individuals with implications for COVID-19 and ARDSArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] 치료제, [키워드] ACE2 ACE2 expression acute respiratory distress alarmin Analysis angiotensin-converting enzyme 2 Antiviral ARDS ARDS patient baseline baseline levels blood sample cause cellular change collected coronavirus disease COVID-19 enrolled enzyme-linked immunosorbent exhibit expression glycyrrhizin healthy individual healthy volunteer HMGB1 hospitalised COVID-19 patient hospitalised patient immunomodulatory property implication in healthy individual in healthy individuals individual individuals liquorice material Mild modulate Non-COVID-19 not different Patient patients pilot study Plasma HMGB1 Potential treatment pro-inflammatory receptor ACE2 reduced reduction in Respiratory disease significantly significantly higher syndrome viral entry were measured with mild disease [DOI] 10.1371/journal.pone.0275181 PMC 바로가기
Spectral and theoretical study of SARS-CoV-2 ORF10 protein interaction with endogenous and exogenous macroheterocyclic compoundsSARS-CoV-2 ORF10 단백질과 내인성 및 외인성 거대 이종고리 화합물 상호작용에 대한 스펙트럼 및 이론 연구Article Published on 2022-10-152022-09-11 Journal: Spectrochimica acta. Part A, Molecular and biomole [Category] COVID19(2023년), SARS, 치료제, [키워드] Accessory accessory protein accessory proteins Alpha Antiviral approved bind carried caused cells Chlorin choice Complexes complexes Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria drug effective drug effective drugs energy Escherichia coli expressed Features form health problem highest affinity Host immune response in silico infected patient infected patients inhibitor inhibitory initial Interaction macrocycle matter modulate molecular docking MOST ORF10 ORF10 protein Orientation pandemic Pathogenesis Porphyrin Pragmatic precedence Protein protoporphyrin public health recommendation resource SARS-CoV-2 SARS-CoV-2 accessory proteins SARS-CoV-2 coronavirus silico studies Spectral Spectroscopy Spectroscopy. Spread Stage suggested Taking the disease the SARS-CoV-2 Treatment treatment of COVID-19 virucidal virus [DOI] 10.1016/j.saa.2022.121403 PMC 바로가기 [Article Type] Article
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spikeArticle Published on 2022-10-062022-11-16 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses Analysis antigenic variation complex COVID-19 Critical Deletion exacerbated fine-tune flexible functional Health Host Immunity mechanism membrane fusion Modification modulate Mutation N-terminal domain NTD omicron polymorphism receptor engagement remained responsible reveal Sarbecoviruses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant spike spike glycoprotein spike stability variant variants variants. Variation Viral transmission virus entry [DOI] 10.15252/embr.202154322 PMC 바로가기